Hbio Thursday and Friday April 30th and May 1st

Journal
Notes...
quiz next class on

•DNA structre
•DNA replication vocabulary words…posted on blog!

DNA Replication Vocabulary see below

Helicase unwinding breaks H bonds (green)

Single Strand Binding Protein stabilizer

DNA Polymerase III adds DNA to primer (orange)

Primase RNA primer (pink)

DNA Polymerase I replaces primer (yellow)

DNA Ligase Glues 5’ and 3’ ends (turquoise)

Topoisomerase corrects over-winding

Origin of Replication where synthesis starts

Leading Strand works towards the replication fork

Lagging Strand works away from the replication fork

Okazaki Fragments lagging strand fragments

Telomers base buffers

Telomerase enzymes that add telomers in germ cells to cancer cells

Parent Strand The strand of DNA that serves as a template to make the “phantom” strand (dark black)

Daughter Strand The strand we are trying to make by using the original DNA template (light blue)

Mismatch pair: incorrect base pairing

Proofreading: done by DNA Polymerase III which removes or adds bases as needed

Nuclease: cuts out the mismatch pair

Nucleotide excision repair: uses ligase and DNA polymerase to fix a mismatch
Polymerase fills gaps
Ligase fuses gaps

friday and monday 4-23 and 4-26

journal
short lecture on diseases
practice genetics worksheet that was turned in for credit

Test next class
Be sure to bring Journals..there are nine total!

Bio Test Delayed

Because of the math final the test for ch 14-15 will occur on:

Period 2+3 = 4-29
Period 6 = 4-28

All other dates remain the same such as when hw packets are due etc.

Wed and Thurs. 4-22 and 4-23 Hbio Period 2,3,6

Journal
Collected HW Packets
Answers to HW packet
Misc. notes
If time, another genetics practice worksheet

Ch 14-15 Exam Next Class

Journals due next class, just a reminder I am only collecting journals that are labeled as "journal 1," "Journals 2, " etc. See prior posting for any journals you may have missed!

NEW JOURNAL…..NEW RULES!!!!!!!!!!
For FULL credit journals MUST be labeled by journal entry!

Journal 1 Chap 14/15
Read page 252 and provide some “facts” about who Mendel was!

Journal 2 Chap 14/15
1) Cross a homozygous dominant tall plant with a heterozygous tall plant and anaylyze the genotypical outcomes of the F1 generation…phenotypical….
2) Which of the following are genotypes and which are gametes?
a. AA
b. A
c. Bb
d. BB
e. C

Journal 3 Chap 14/15
1. BbDD (B brown, D deaf) is mated to one with BBdd. What is the chance of obtaining an offspring that is
a. Brown/NOT deaf?
b. Brown/deaf?
2. When you are done with this journal finish your ws from last class…we are going to have an overhead of notes in just a sec!

Journal 4 Chap 14/15
Do overhead practice problem set 11.5

Journal 5 Chapter 14/15
Considering incomplete dominance and the following key answer the following question.
TA = tall
TB = short
PR = purple
PQ = white

Parents = TATBPRPQ x TATAPRPR

1. What are the chances of having a medium/lilac flower?

Journal 6 Chapter 14/15
gene
allele
principle of segregation
principle of independent assortment

different forms of a gene for the same trait

The law that states the different forms of two alleles (homologous chromosomes) will separate independently of each other into different gametes

a segment/piece of DNA that codes for a trait

This law states that factors for different characters (on different chromosomes) separate independently of each other. This is why you have to consider EVERY possible combination that can occur when you are tracking a dihybrid cross

Journal 7 Chapter 14/15
1. Using pages 265-268 make a list of all the autosomal dominant and a list of the autosomal recessive inherited disorders and provide a brief explanation of each.
2. Note to self, please be sure to read and understand pages section 15.4 of your book. We may not be going over this in class but it will be on the test! Show PPT on this from notes!
3. Today Jenkins will show you some examples of sex chromos altered

Journal 8 Chapter 14/15

Make sure your journals are in order for next class when they will be checked off

Make sure to pay attention to chromosomal # abnormalities and autosomal dom/rec and sex linked diseases info..see blog for full description

1. Explain why generally, it is not possible to determine whether nondisjunction failed to occur in oogenesis or spermatogenesis. However, it is possible to assert that xyy resulted in nondisjunction in spermatogenesis

Decide whether the following statements apply to amniocentesis “A” or chorionic Villa Sampling “B”

2. Obtains cells from the region where the placenta will develop
3. Takes a sample from the amniotic fluid from the uterus
4. Can determine more types of abnormalities. In other words, is not limited to just a disorders revealed by a karyotype
5. Of the two procedures, this test has the lowest risk of a spontaneous abortion
6. This test can be done earlier in the pregnancy

7. Decide the inheritance pattern of the following pedigrees….be ready to explain!

Journal 9 ch 14-15
Mom: Dad
homozygous hemophilia Has hemophilia
homozygous cystic fibrosis carrier of cystic fibrosis
blood type AB Homozygous for blood B
Rh- Heterozygous Rh+
Heterozygous for Huntington’s Disease Heterozygous for Huntington’s


Showing your work mathematically, please give me the phenotypical fraction among all the offspring
that will be male hemophiliacs, with cystic fibrosis, blood type BB, Rh+, with Huntington’s
disease. Yes, I know this kid was dealt a bad hand of cards!

Mon and Tues 4-20 and 4-21 HBio

Journal
Notes on pedigrees and misc items so you could finish your HW packets
pedigree worksheet that was turned it at class end

HW packets due next class
Please see below info for disease info that may be helpful for your test...some of these are in your books!


•Tay-Sachs Disease
–Progressive deterioration of psychomotor functions due to lacking hex A enzyme and the ability to store it’s lipid substrate
–Causes build up of lipids in the brain
–1:3,600 Jewish have the disorder
–Developing symptoms 4-8mths old
–Child gradually becomes blind and helpless, seizures, paralyzed
–Death by age 3 – 4 No cure


•Cystic Fibrosis
–Mucus in bronchial tubes and pancreatic ducts is particularly thick and viscous due to lack of water due to the NaCl pump not working.
–Most common lethal genetic disorders among Caucasians
–1:20 Caucasians is a carrier
–1:3,000 newborns have disorder
–Clogged pancreatic ducts do not allow digestive enzymes to reach stomach so apple sauce mixed with digestive enzymes is taken before every meal
–Die by age 37
–Have isolated gene on chromosome #7


•Phenylketonuria (PKU)
–Lack enzyme for normal metabolism of phenylalanine which effects nervous system development
•Need to change aa (phenylalanine) into another aa (tyrosine)
–Gene on Chromosome #12
–Lack enzyme needed to break down the amino acid PKU
–PKU accumulates in the urine
–Tested at birth, placed on low PKU diet until brain is developed…age 7 some for lifePregnant woman must be on low PKU diet to protect unborn baby


•Neurofibromatosis
–Tan or dark spots develop on skin and darken. Small, benign tumors may arise from fibrous nerve coverings
–Equal among all ethnic groups
–Many children with the disorder have hyperactivity and learning disabilities
–Chromosome # 17


•Huntington Disease
–Neurological disorder leading to progressive degeneration of brain cells, in turn causing severe muscle spasms and personality disorders
–1:20,000 people are affected with a mutation of the gene on chromo 4
–The huntington protein has too many copies of AA Glutamine in the protein
–Normal is 10-25 glutamines long
–Affected have a protein with 36+ glutamines
•Changes shape and forms large clumps in nervous system and causes other proteins to clump to it
–Unaffected until middle age
–There is a test, would you want to be tested?

thurs and fri 4/16 and 4/16

Journal while Jenkins checked off your worksheets
Answers to worksheets
quiz on genetics up to this point
blood lab...when you are done with the quiz...work on your HW packets if you finished early while the others finished the lab
notes on chromosomal number abnormalities

HW packets are due wed 22nd and 23rd unless otherwise stated...

Test scheduled for friday the 24th and 27th depending on what period I have you!

Tues and Wed 4/14 and 4/15

Journal
collected babies from last class that you were supposed to finish as hw
Misc. notes
Sex linked notes
Blood lab and sex linked ws

HW:
1. Study for quiz you are having next class on...
vocab
blood typing
sex linked
dihybrid
incomplete dominance
codominance
2. Finish sex linked, mult allele ws for HW...answers next class

AP Study Session Dates/Topics!
2:45-4:00 starting promtly each day! If you come in late, please come in quietly and join in on the study session!

4-15 unit four of study guide...focus on Hardy-Weinberg
4-23 Anatomy and Physiology focus on Muscles, cardiovascualr system, immune system and
misc. orginization
4-29 plants
5-7 Day for you to come in and take some of the practice exams in your study guide

Tues and Wed 47 and 4/8

journal
answers to di and mono ws
finished blood notes
did blood ws

Make sure you have started your HW packet by now!
Jenkins will be out on Thursday for a field trip!

fri and monday 4/3 and 4/6

jounrnal
notes on mult and addition law'
notes on codom/incomplete dom/blood
finished your mono and dihybrid ws in class....please finish for HW as the answers will be given next class!

wed and thursday 4/1 and 4/2 HBio

Journal
Collected your mitosis projects
Changed seats
Passed out YUMMY brownies!
did some dihybrid MATH
Started a monohybrid and dihybrid worksheet that you did not have time to finish
You will get the first 10 minutes of next class to finish the above worksheets